Peer-Reviewed Publications:
Connor DE, Paulus JA, Dabestani PJ, Thankam FK, Dilisio MF, Gross RM, Agrawal DK. Therapeutic potential of exosomes in rotator cuff tendon healing. J Bone Miner Metab. 2019 Jun 1. doi: 10.1007/s00774-019-01013-z. PubMed PMID: 31154535.
Thankam FG, Dilisio MF, Gross RM, Agrawal DK. Collagen I: a kingpin for rotator cuff tendon pathology. Am J Transl Res. 2018 Nov 15;10(11):3291-3309. eCollection 2018. Review. PubMed PMID: 30662587; PubMed Central PMCID: PMC6291732.
Thankam FG, Chandra IS, Kovilam AN, Diaz CG, Volberding BT, Dilisio MF, Radwan MM, Gross RM, Agrawal DK. Amplification of Mitochondrial Activity in the Healing Response Following Rotator Cuff Tendon Injury. Sci Rep. 2018 Nov 19;8(1):17027. doi: 10.1038/s41598-018-35391-7. PubMed PMID: 30451947; PubMed Central PMCID: PMC6242817.
Thankam FG, Boosani CS, Dilisio MF, Agrawal DK. Epigenetic mechanisms and implications in tendon inflammation (Review). Int J Mol Med. 2019 Jan;43(1):3-14. doi: 10.3892/ijmm.2018.3961. Epub 2018 Oct 29. Review. PubMed PMID: 30387824; PubMed Central PMCID: PMC6257858.
Thankam FG, Boosani CS, Dilisio MF, Gross RM, Agrawal DK. Genes interconnecting AMPK and TREM-1 and associated microRNAs in rotator cuff tendon injury. Mol Cell Biochem. 2019 Apr;454(1-2):97-109. doi: 10.1007/s11010-018-3456-z. Epub 2018 Oct 10. PubMed PMID: 30306456; PubMed Central PMCID: PMC6438203.
Thankam FG, Evan DK, Agrawal DK, Dilisio MF. Collagen type III content of the long head of the biceps tendon as an indicator of glenohumeral arthritis. Mol Cell Biochem. 2018 Sep 28. doi: 10.1007/s11010-018-3449-y. PubMed PMID: 30267195.
Dilisio MF. Editorial Commentary: Get Ready to Download the i-Cuff App: Developing the Rotator Cuff Irreparability Equation. Arthroscopy. 2018 Jul;34(7):2085-2086. doi: 10.1016/j.arthro.2018.03.025. PubMed PMID: 29976425.
Thankam FG, Roesch ZK, Dilisio MF, Radwan MM, Kovilam A, Gross RM, Agrawal DK.Association of Inflammatory Responses and ECM Disorganization with HMGB1
Upregulation and NLRP3 Inflammasome Activation in the Injured Rotator Cuff
Tendon. Sci Rep. 2018 Jun 11;8(1):8918. doi: 10.1038/s41598-018-27250-2. PubMed
PMID: 29891998.
Dilisio MF. Editorial Commentary: Our Mentors Were Right, New Is Not Always Better: The Posterolateral Shoulder Trans-Rotator Cuff Portal Is Safe for SLAP Repairs. Arthroscopy. 2017 February 2018 Volume 34, Issue 2, Pages 396–397 DOI: https://doi.org/10.1016/j.arthro.2017.11.006
Fouda MB, Thankam FG, Dilisio MF, Agrawal DK. Alterations in tendon microenvironment in response to mechanical load: potential molecular targets for treatment strategies. Am J Transl Res. 2017 Oct 15;9(10):4341-4360. eCollection 2017. Review. PubMed PMID: 29118899; PubMed Central PMCID: PMC5666046.
Fehringer EV, Dilisio MF, Greco CE, Fleming SM, Brezenski JW, High RR. Changing Body Movement Patterns in 9-Year-Old Baseball Pitchers: A Pilot Study. Orthop J Sports Med. 2017 Jun 28;5(6):2325967117713023. Doi: 10.1177/2325967117713023. eCollection 2017 Jun. PubMed PMID: 28695140; PubMed Central PMCID: PMC5495506.
Garfinkel RJ, Dilisio MF, Agrawal DK. Vitamin D and Its Effects on Articular Cartilage and Osteoarthritis. Orthop J Sports Med. 2017 Jun 20;5(6):2325967117711376. doi: 10.1177/2325967117711376. eCollection 2017 Jun. Review. PubMed PMID: 28680892; PubMed Central PMCID: PMC5480771.
Raney EB, Thankam FG, Dilisio MF, Agrawal DK. Pain and the pathogenesis of biceps tendinopathy. Am J Transl Res. 2017 Jun 15;9(6):2668-2683. eCollection 2017. Review. PubMed PMID: 28670360; PubMed Central PMCID: PMC5489872.
Thankam FG, Boosani CS, Dilisio MF, Agrawal DK. MicroRNAs associated with inflammation in shoulder tendinopathy and glenohumeral arthritis. Mol Cell Biochem. 2017 Jun 20. doi: 10.1007/s11010-017-3097-7. [Epub ahead of print] PubMed PMID: 28634854.
Rosenberg JH, Rai V, Dilisio MF, Sekundiak TD, Agrawal DK. Increased expression of damage-associated molecular patterns (DAMPs) in osteoarthritis of human knee joint compared to hip joint. Mol Cell Biochem. 2017 Jun 1. Doi: 10.1007/s11010-017-3078-x.
Rosenberg JH, Rai V, Dilisio MF, Agrawal DK. Damage-associated molecular patterns in the pathogenesis of osteoarthritis: potentially novel therapeutic targets. Mol Cell Biochem. 2017 May 4. doi: 10.1007/s11010-017-3047-4.
Rai V, Dilisio MF, Dietz NE, Agrawal DK. Recent strategies in cartilage repair: A systemic review of the scaffold development and tissue engineering. J Biomed Mater Res A. 2017 Aug;105(8):2343-2354. doi: 10.1002/jbm.a.36087. Epub 2017 May 10. Review. PubMed PMID: 28387995.Thankam FG, Boosani CS, Dilisio MF, Dietz NE, Agrawal DK. MicroRNAs Associated with Shoulder Tendon Matrisome Disorganization in Glenohumeral Arthritis. PLoS One. 2016 Dec 16;11(12):e0168077. doi: 10.1371/journal.pone.0168077.
Thankam FG, Dilisio MF, Dietz NE, Agrawal DK. TREM-1, HMGB1 and RAGE in the Shoulder Tendon: Dual Mechanisms for Inflammation Based on the Coincidence of Glenohumeral Arthritis. PLoS One. 2016 Oct 28;11(10):e0165492. Doi: 10.1371/journal.pone.0165492.
Thankam FG, Dilisio MF, Dougherty KA, Dietz NE, Agrawal DK. Triggering receptor expressed on myeloid cells and 5'adenosine monophosphate-activated protein kinase in the inflammatory response: a potential therapeutic target. Expert Rev Clin Immunol. 2016 Nov;12(11):1239-1249.
Rai V, Dietz NE, Dilisio MF, Radwan MM, Agrawal DK. Vitamin D attenuates inflammation, fatty infiltration, and cartilage loss in the knee of hyperlipidemic microswine. Arthritis Res Ther. 2016 Sep 13;18(1):203. doi: 10.1186/s13075-016-1099-6.
Dougherty KA, Dilisio MF, Agrawal DK. Vitamin D and the immunomodulation of rotator cuff injury. J Inflamm Res. 2016 Jun 14;9:123-31. Doi: 10.2147/JIR.S106206. eCollection 2016. Review. PubMed PMID: 27366101; PubMed Central PMCID: PMC4913983.
Dilisio MF, Warner JJ, Walch G. Accuracy of the Subchondral Smile and Surface Referencing Techniques in Reverse Shoulder Arthroplasty. Orthopedics. 2016 Jun 17:1-6. doi: 10.3928/01477447-20160610-04.
Thankam FG, Dilisio MF, Agrawal DK. Immunobiological factors aggravating the fatty infiltration on tendons and muscles in rotator cuff lesions. Mol Cell Biochem. 2016 Jun;417(1-2):17-33. doi: 10.1007/s11010-016-2710-5.
Dilisio MF, Nowinski RJ, Hatzidakis AM, Fehringer EV. Intramedullary nailing of the proximal humerus: evolution, technique, and results. J Shoulder Elbow Surg. 2016 May;25(5):e130-8. doi: 10.1016/j.jse.2015.11.016.
Dilisio MF, Warner JJ, Higgins LD. “Arthroscopic Tissue Biopsy to Diagnose Recurrent Shoulder Infection after Articulating Antibiotic Cement Spacer Placement.” 4/2016. Accepted for Publication: International Journal of Shoulder Surgery.
Lee AH, Dilisio MF, Warner JJ. Late Dissociation of the Humeral Head Morse Taper Associated with Periprosthetic Proximal Humerus Fracture. JBJS Case Connect, 2016 May 11; 6 (2): e34 . http://dx.doi.org/10.2106/JBJS.CC.15.00111
Dilisio MF, May NR, Vincent SA, High RR, Walker CW, Manzer MN, Apker KA, Fehringer EV. The association of incomplete glenoid component seating and periprosthetic glenoid radiolucencies after total shoulder arthroplasty. J Shoulder Elbow Surg. 2016 Mar;25(3):442-7. doi: 10.1016/j.jse.2015.08.005.
Dilisio MF, Miller LR, Siegel EJ, Higgins LD. Conversion to Reverse Shoulder Arthroplasty: Humeral Stem Retention Versus Revision. Orthopedics. 2015 Sep 1;38(9):e773-9. doi: 10.3928/01477447-20150902-54.
Pfefferle KJ, Dilisio MF, Patti B, Fening SD, Junko JT. Transparency to Reduce Surgical Implant Waste. Clin Orthop Surg. 2015 Jun;7(2):207-10. doi: 10.4055/cios.2015.7.2.207. Epub 2015 May 18.
Dilisio MF, Noel CR, Noble JS, Bell RH. Traumatic Supraspinatus Tears in Patients Younger Than 25 Years. Orthopedics. 2015 Jul 1;38(7):e631-4. doi: 10.3928/01477447-20150701-63.
Parada SA, Dilisio MF, Kennedy CD. Management of complications after rotator cuff surgery. Curr Rev Musculoskelet Med. 2015 Mar;8(1):40-52. doi: 10.1007/s12178-014-9247-6.
Dilisio MF, Miller LR, Siegel EJ, Higgins LD. Conversion to Reverse Shoulder Arthroplasty: Humeral Stem Retention Versus Revision. Orthopedics. 2015 Sep 1;38(9):e773-9. doi: 10.3928/01477447-20150902-54.
Dilisio MF, Neyton L. Comma sign-directed repair of anterosuperior rotator cuff tears. Arthrosc Tech. 2014 Dec 1;3(6):e695-8. doi: 10.1016/j.eats.2014.09.001.
Dilisio MF, Miller LR, Warner JJ, Higgins LD. Arthroscopic tissue culture for the evaluation of periprosthetic shoulder infection. J Bone Joint Surg Am. 2014 Dec 3;96(23):1952-8. doi: 10.2106/JBJS.M.01512.
Dilisio MF, Miller LR, Higgins LD. Transtendon, double-row, transosseous-equivalent arthroscopic repair of partial-thickness, articular-surface rotator cuff tears. Arthrosc Tech. 2014 Sep 8;3(5):e559-63. doi: 10.1016/j.eats.2014.06.007.
Parada SA, Dilisio MF, Miller LR, Higgins LD. Long head of the biceps tendon allis clamp evaluation technique. Arthrosc Tech. 2014 Aug 4;3(4):e491-3. doi: 10.1016/j.eats.2014.05.003.
Dilisio MF. Osteonecrosis following short-term, low-dose oral corticosteroids: a population-based study of 24 million patients. Orthopedics. 2014 Jul;37(7):e631-6. doi: 10.3928/01477447-20140626-54.
Pfefferle KJ, Shemory ST, Dilisio MF, Fening SD, Gradisar IM. Risk factors for manipulation after total knee arthroplasty: a pooled electronic health record database study. J Arthroplasty. 2014 Oct;29(10):2036-8. doi: 10.1016/j.arth.2014.05.001.
Pfefferle KJ, Gil KM, Fening SD, Dilisio MF. Validation study of a pooled electronic healthcare database: the effect of obesity on the revision rate of total knee arthroplasty. Eur J Orthop Surg Traumatol. 2014 Dec;24(8):1625-8. doi: 10.1007/s00590-014-1423-2.
Dilisio MF, Noble JS, Bell RH, Noel CR. Postarthroscopic humeral head osteonecrosis treated with reverse total shoulder arthroplasty. Orthopedics. 2013 Mar;36(3):e377-80. doi: 10.3928/01477447-20130222-30.
Dilisio MF, Fitzgerald RE, Miller ET. Extended Neviaser portal approach to antegrade humeral nailing. Orthopedics. 2013 Feb;36(2):e244-8. doi: 10.3928/01477447-20130122-30.
Callahan LA, Ganios AM, McBurney DL, Dilisio MF, Weiner SD, Horton WE Jr, Becker ML. ECM production of primary human and bovine chondrocytes in hybrid PEG hydrogels containing type I collagen and hyaluronic acid. Biomacromolecules. 2012 May 14;13(5):1625-31. doi: 10.1021/bm3003336.
Books Chapters
Dilisio MF, Elhassan B. Higgins LD, Warner JJ. “The Stiff Shoulder” in Rockwood C. The Shoulder. 5th Edition.Elsevier, 2015. Print.
Parada SA, Dilisio MF, Warner JJ, Higgins LD. “Reverse Shoulder Arthroplasty for Massive Rotator Cuff Tears Without Glenohumeral Arthritis.” In Frankle MA. Reverse Shoulder Arthroplasty. Springer Science, 2015. Print
Warner JJ, Dilisio MF, Elhassan B. “Snapping Scapula Syndrome.” In Wiesel SW. Operative Techniques in Orthopaedic Surgery. Philadelphia: Lippincott Williams & Wilkins, 2015. Print.
Dilisio MF, Parada SA, Warner JJ. “Arthroscopic Pan Labral Repair.” In Ryu RK, Angelo RL, Abrams JS. The Shoulder: AANA Advanced Arthroscopic Surgical Techniques. Philadelphia, PA: Saunders/Elsevier, 2015. Print.
National Research Presentations
Thankam FG, Agrawal DK, Gross RM, Dilisio MF. “The Role of TREM Proteins in Juvenile Rotator Cuff Regeneration.” 4/2018 Mid-America Orthopaedic Society 2018 Annual Meeting. San Antonio, TX (Podium Presentation)
Dilisio MF“2017-2018 MAOA Traveling Fellow Presentation.” 4/2018 Mid-America Orthopaedic Society 2018 Annual Meeting. San Antonio, TX (Podium Presentation)
Dilisio MF, Thankam FG, Agrawal DK. “Why Does the Proximal Biceps Tendon Hurt? A Collagen Profile Analysis of the Symptomatic Long Head of the Biceps Tendon.” 4/2017 Mid-America Orthopaedic Society 2017 Annual Meeting. Bonita Springs, FL (Podium Presentation)
Fehringer EV, Dilisio MF,Greco C, Fleming S, Brezenski JA, High RR.. “Changing Body Movement Patterns in 9-Year Old Baseball Throwers: A Pilot Study.” 4/2017 Mid-America Orthopaedic Society 2017 Annual Meeting. Bonita Springs, FL (Podium Presentation)
Dilisio MF, Warner JJ, Walch G. “Accuracy of the Subchondral Smile and Surface Referencing Techniques to Obtain Inferior Baseplate Tilt in Reverse Shoulder Arthroplasty.” 4/2016 Mid-America Orthopaedic Society 2016 Annual Meeting. Bonita Springs, FL (Podium Presentation)
Dilisio MF, Warner JJ, Walch G. “Accuracy of the Subchondral Smile and Surface Referencing Techniques to Obtain Inferior Baseplate Tilt in Reverse Shoulder Arthroplasty.” 6/2015 32nd Annual San Diego Shoulder Institute Meeting. San Diego, CA (Poster Presentation)
Dilisio MF, Warner JJ, Miller LR, Higgins LD. “Arthroscopic Tissue Culture for the Evaluation of Periprosthetic Shoulder Infection.” 4/2015. Mid-America Orthopaedic Society 2015 Annual Meeting. Hilton Head Island, SC (Podium Presentation)
Dilisio MF, Miller LR, Siegel E, Higgins LD. “Humeral Stem Revision Versus Retention in the Conversion of Failed Shoulder Arthroplasty to Reverse Total Shoulder Arthroplasty: the Utilization of a Platform System.” 4/2015. Mid-America Orthopaedic Society 2015 Annual Meeting. Hilton Head Island, SC ( Podium Presentation)
Dilisio MF, Warner JJ, Miller LR, Higgins LD. “Arthroscopic Tissue Culture for the Evaluation of Periprosthetic Shoulder Infection.” 3/2015. American Academy of Orthopaedic Surgeons Annual Meeting. Las Vegas, NV (Podium Presentation)
Dilisio MF, Neyton L. “Comma Sign-Directed Repair of Anterosuperior Rotator Cuff Tears.” 11/2014. The French Society of Orthopaedic and Trauma Surgery (SOFCOT) Annual Congress. Paris, France. (Podium Presentation)
Widmer S, Dilisio MF, Gradisar I. “Bariatric Surgery May Decrease Acute Postoperative Total Knee Arthroplasty Complications in the Morbidly Obese: A Comparative Study Using an Electronically Pooled Database.” 4/2014. Mid-America Orthopaedic Society 2014 Annual Meeting. San Antonio, TX (Podium Presentation, Physician in Training Award Finalist)
Pfefferle KJ, Shemory ST, Dilisio MF, Fening SD, Gradisar I. "Risk Factors for Manipulation After Total Knee Arthroplasty: A Pooled Electronic Health Record Database Study." 4/2014. Mid-America Orthopaedic Society 2014 Annual Meeting. San Antonio, TX (Podium Presentation)
PfefferleKJ, Gil K, Fening SD, Dilisio MF. “The Effect of Obesity on the Revision Rate of Total Knee Arthroplasty: a Population Based Validation Study of a Pooled Electronic Healthcare Database." 4/2014. Mid-America Orthopaedic Society 2014 Annual Meeting. San Antonio, TX (Podium Presentation)
Yi SJ, Shemory S, Patel R, Brower RS., Dilisio MF. "The Utility of Inpatient Spine Surgery Consults in Patients Over the Age of 65 for Pain and Radiculopathy4/2014. Mid-America Orthopaedic Society 2014 Annual Meeting. San Antonio, TX (Podium Presentation)
Pfefferle KJ, Shemory ST, Dilisio MF, Fening SD, Gradisar I. "Risk Factors for Manipulation After Total Knee Arthroplasty: A Pooled Electronic Health Record Database Study." 3/2014. Orthopaedic Research Society Annual Meeting. New Orleans, LA (Poster Presentation)
Pfefferle KJ, Shemory ST, Dilisio MF, Fening SD, Gradisar I. "Risk Factors for Manipulation After Total Knee Arthroplasty: A Pooled Electronic Health Record Database Study." 3/2014. American Academy of Orthopaedic Surgery Annual Meeting. New Orleans, LA (Podium Presentation)
PfefferleKJ, Gil K, Fening SD, Dilisio MF. “The Effect of Obesity on the Revision Rate of Total Knee Arthroplasty: a Population Based Validation Study of a Pooled Electronic Healthcare Database." 11/2013. American Association of Hip and Knee Surgeons Annual Meeting. Dallas, TX (Poster Presentation)
Dilisio MF, Noel CR, Noble JS, Bell RH. "Traumatic Rotator Cuff Tears in Patients Under the Age of 25." 4/2013. Arthroscopy Association of North America 2013 Annual Meeting. San Antonio, TX. (Poster Presentation)
Dilisio MF, Noel CR, Noble JS, Bell RH. "Traumatic Rotator Cuff Tears in Patients Under the Age of 25." 4/2013. Mid-America Orthopaedic Society 2013 Annual Meeting. Amelia Island, FL. (Podium Presentation)
Dilisio MF, Neal D, Horton WE, Puskas JE, Luebbers M, Weiner SD, Mostardi RA. “The Effect of Oxygen Tension, Hydrogel Suspension, and Rubber-Derived Polymer Seeding on Bioengineered Human Cartilage Implants.” 4/2013. Mid-America Orthopaedic Society 2013 Annual Meeting. Amelia Island, FL. (Podium Presentation)
Dilisio MF, Noel CR, Noble JS, Bell RH. "Traumatic Rotator Cuff Tears in Patients Under the Age of 25." 3/2013. American Academy of Orthopaedic Surgery Annual Meeting. Chicago, IL (Poster Presentation)
Dilisio MF, Noel CR, Noble JS, Bell RH. "Traumatic Rotator Cuff Tears in Patients Under the Age of 25." 1/2013. Orthopaedic Research Society Annual Meeting. San Antonio, TX (Poster Presentation)
Dilisio MF, Noel CR, Noble JS, Bell RH. "Traumatic Rotator Cuff Tears in Patients Under the Age of 25." 10/2012. American Shoulder and Elbow Surgeons Annual Closed Meeting. Sea Island, Georgia. (Poster Presentation)
Dilisio MF, Smith LA, Horton WE, Weiner SD, Becker ML. "Establishing Chondrocyte Culture on a Self-Assembled Monolayer." 4/2012. Mid-America Orthopaedic Society 2012 Annual Meeting. Bonita Springs, FL. http://icjr.net/media/video.3352.html (Poster Presentation, Online Oral Presentation)
Dilisio MF, Horton WE, McBurney D, Nugent AE, Speering LM, Sieve R, Wong SC, Smith LA, Ganios A, Becker ML. Weiner SD. "Bioengineered Hyaline Cartilage from Human and Bovine Chondrocytes Embedded in Polyethylene Glycol and Electrospun Polycaprolactone Polymer Scaffolds." 4/2011. Mid-America Orthopaedic Association 2011 Annual Meeting. Tucson, AZ. http://icjr.net/media/video.1772.html (Poster Presentation, Online Oral Presentation)
Regional Research Presentations: 12
Local Research Presentations: 29
Invited Lectures: 17
His current research line involves: 1. Patient outcomes research so that we measure and compare what we do to ensure that we are achieving the highest possible outcomes.
2. Implant and technique development in order to push technology in orthopaedics forward.
3. Optimizing rotator cuff healing.4. Understanding the cause and pain pathways of tendon-related shoulder pain.
Research and Publications
Orthopedics Today recently interviewed Dr. Larry Higgins about Dr. Dilisio's article on revision shoulder replacement.
Dr. Dilisio's recent peer-reviewed publications
Dr. Dilisio is an associate professor of orthopaedic surgery at Creighton University School of Medicine and a member of the editorial board for the Journal of Arthroscopy and the Journal of Orthopedics. He believes that research and education are essential in order to improve patient care and push the field of orthopaedic surgery forward. He continues to publish and present his research around at the national level. He has a utility patent for a cartilage restoration implant, and has received several local, regional, and national awards for his Work.